Genetics

Investigating the role of Brd4 in diet-induced obesity

A new study, published in JCI Insight, looks at how Brd4, a regulator of the innate immune response, influences diet-induced obesity. The researchers believe that Brd4 could be used as a target for obesity and insulin resistance.

Medical research

Glucose acts as a double edged sword on longevity factor SIRT1

Feeding and fasting cycles exert control over metabolism and energy utilization. Aberrations are known to cause metabolic diseases, liver dysfunctions and accelerated aging. Expression and activity of the anti-aging factor ...

Neuroscience

Cancer-like metabolism makes brain grow

The size of the human brain increased profoundly during evolution. A certain gene that is only found in humans triggers brain stem cells to form a larger pool of stem cells. As a consequence, more neurons can arise, which ...

Medical research

Engineering lymphatic vessels as a therapeutic to heal the heart

The cardiovascular system is a complex network of veins, arteries and capillaries. Within that network, lymphatic vessels are critical to the heart's ability to heal in the event of a heart attack. When they're functional, ...

Medical research

Micro-control of liver metabolism

Researchers at TIFR have discovered molecular anticipation of feeding in the liver that is essential to ensure that the body, after fasting, adapts to use incoming nutrients upon re-feeding. Their findings, published in the ...

Neuroscience

Hypothalamus neurons modulate pancreatic insulin amounts

The brain is key in the regulation of appetite, body weight and metabolism. Specifically, there is a small group of POMC neurons in the hypothalamus that detect and integrate signals related to the body's energy state and ...

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