Diseases, Conditions, Syndromes

Flower nectar offers new weapon against Leishmaniasis

The nectar of common plants such as sunflower contain bioactive agents that can inhibit the growth of Leishmania and could be used to help fight the potentially fatal disease caused by the parasite, say researchers.

Diabetes

Active brown adipose tissue protects against 'pre-prediabetes'

In a prospective study of young, lean adults, PET/CT imaging revealed that higher levels of active brown adipose tissue (also known as "brown fat") are more prevalent in individuals who exhibit very early indications of metabolic ...

Alzheimer's disease & dementia

New Alzheimer's biomarker may facilitate rapid diagnosis

Although symptoms of advanced Alzheimer's disease are well known, diagnosis of Alzheimer's disease in its earliest stages requires careful cognitive testing by neurologists.

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Metabolite

Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. A primary metabolite is directly involved in normal growth, development, and reproduction. Alcohol is an example of a primary metabolite produced in large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments. Some antibiotics use primary metabolites as precursors, such as actinomycin which is created from the primary metabolite, tryptophan.

Examples of primary metabolites produced by industrial microbiology:

The metabolome forms a large network of metabolic reactions, where outputs from one enzymatic chemical reaction are inputs to other chemical reactions.

Metabolites from chemical compounds, whether inherent or pharmaceutical, are formed as part of the natural biochemical process of degrading and eliminating the compounds. The rate of degradation of a compound is an important determinant of the duration and intensity of its action. Profiling metabolites of pharmaceutical compounds, drug metabolism, is an important part of drug discovery, leading to an understanding of any undesirable side effects.

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