Neuroscience

Brain makes its own version of Valium, researchers find

Researchers at the Stanford University School of Medicine have found that a naturally occurring protein secreted only in discrete areas of the mammalian brain may act as a Valium-like brake on certain types of epileptic seizures.

Cardiology

Researchers discover new link between heart disease and red meat

A compound abundant in red meat and added as a supplement to popular energy drinks has been found to promote atherosclerosis – or the hardening or clogging of the arteries – according to Cleveland Clinic research published ...

Medical research

Facilitating diagnosis with a new type of biosensor

Scientists from the Max Planck Institute and EPFL have developed a new type of biosensor able to precisely quantify metabolites using a single drop of blood. The accuracy and simplicity of the procedure could make it a tool ...

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Metabolite

Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. A primary metabolite is directly involved in normal growth, development, and reproduction. Alcohol is an example of a primary metabolite produced in large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments. Some antibiotics use primary metabolites as precursors, such as actinomycin which is created from the primary metabolite, tryptophan.

Examples of primary metabolites produced by industrial microbiology:

The metabolome forms a large network of metabolic reactions, where outputs from one enzymatic chemical reaction are inputs to other chemical reactions.

Metabolites from chemical compounds, whether inherent or pharmaceutical, are formed as part of the natural biochemical process of degrading and eliminating the compounds. The rate of degradation of a compound is an important determinant of the duration and intensity of its action. Profiling metabolites of pharmaceutical compounds, drug metabolism, is an important part of drug discovery, leading to an understanding of any undesirable side effects.

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