Oncology & Cancer

Scientists crack structure of enzyme complex linked to cancer

A research team led by a biochemist at the University of California, Riverside has solved the crystal structure for an enzyme that plays a key role in DNA methylation, the process by which methyl groups are added to the DNA ...

Medical research

New computational method reveals chemoresistance drug targets

Osaka – In cancer, one of the most important features is the methylation of deoxycytosine to form 5-methylcytosine (5mC). DNA methylation is a process by which methyl groups (structural units of organic compounds consisting ...

Oncology & Cancer

Risk for some cancers may be determined before birth

Normal tissue BRCA1 methylation is associated with risk for high-grade ovarian cancer and may occur as a prenatal event. These findings are published in Annals of Internal Medicine.

Oncology & Cancer

DNA annotations predict patient outcomes in childhood leukemia

UC San Francisco physician-scientists have developed a test that can predict how patients with juvenile myelomonocytic leukemia (JMML) will respond to treatment, and may also be able to identify patients who are likely to ...

Immunology

Immune cells turn back time to achieve memory

Memory T cells earn their name by embodying the memory of the immune system - they help the body remember what infections or vaccines someone has been exposed to. But to become memory T cells, the cells go backwards in time, ...

Genetics

Immune diseases inflict identical twins differently

Any parent with identical twins knows their two children are actually remarkably different. Identical twins are genetically identical, but they are not identical in gene expressions, a difference attributable to epigenetics. ...

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