The complex interplay between extracellular genetic material and the tumor's genetic landscape presents a significant challenge in grasping cancer evolution, tumor genetic heterogeneity, and treatment response. Earlier research ...
Aug 9, 2024
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Progenitor exhausted CD8+ T (Tpex) cells have emerged as a pivotal component in tumor immunotherapy due to their unique ability to self-renew and rapidly proliferate. These cells have shown promise in expanding and differentiating ...
Aug 8, 2024
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A new study reviews how cancer-associated fibroblasts (CAFs) influence lymph node metastasis. Researchers identified various CAF subsets that interact with the tumor microenvironment, promoting cancer spread.
Aug 8, 2024
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The complex dynamics between liver cancer stem cells (CSCs) and immune cells within the tumor microenvironment (TME) are central to the progression of liver cancer. These interactions are critical in creating an immunosuppressive ...
Aug 7, 2024
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A protein called Meteorin-like (METRNL) in the tumor microenvironment saps energy from T cells, thereby severely limiting their ability to fight cancer, according to new research directed by investigators at the Johns Hopkins ...
Aug 6, 2024
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Yu-Hwa Huang, Ph.D. and Charles Yoon, MD, of the Department of Medicine and Department of Surgery at Brigham and Women's Hospital respectively, are co-lead authors of a paper titled "High-dimensional mapping of human CEACAM1 ...
Aug 6, 2024
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A research paper has been published in Oncotarget titled, "INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment ...
Aug 6, 2024
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Researchers probing the next frontiers in cancer therapy have turned to bacteria given their ability to inhibit tumor proliferation by colonizing tumors. Crucially, the Achilles heel of this approach is suboptimal treatment ...
Jul 1, 2024
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In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team from UZH and USZ has now discovered that a factor secreted by tumor cells is responsible for the resistance. These findings ...
Jun 27, 2024
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While the overall five-year survival rate for pancreatic cancer is slowly improving, it remains discouragingly low—just 13%, according to the American Cancer Society. And the odds are even worse if the cancer is discovered ...
Jun 24, 2024
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