Mount Sinai researchers have achieved an unprecedented understanding of the genetic and molecular machinery in human microglia—immune cells that reside in the brain—that could provide valuable insights into how they contribute ...
Aug 5, 2022
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One of the hallmarks of Alzheimer's disease is a reduction in the firing of some neurons in the brain, which contributes to the cognitive decline that patients experience. A new study from MIT shows how a type of cells called ...
Aug 4, 2022
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A team of researchers working at McGill University has found that activation of microglia in the spinal cord following a nerve injury can lead to an increased sensitivity to pain. In their paper published in the journal Science, ...
Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have found that oral administration of rapamycin to an Alzheimer's disease mouse model causes an increase in beta (β)-amyloid ...
Jun 7, 2022
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The repurposing of FDA-approved drugs for alternative diseases is a faster way of bringing new treatments into the clinic. Researchers at Karolinska Institutet in Sweden have repurposed a cancer drug for treatment of neuroinflammatory ...
Jun 6, 2022
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New research in mice raises the prospects for development of post-concussion therapies that could ward off cognitive decline and depression, two common conditions among people who have experienced a moderate traumatic brain ...
May 3, 2022
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Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and thereby slow the disease process in Alzheimer's and some other neurodegenerative diseases, suggests a study by Weill ...
Apr 14, 2022
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Genetic mutations linked to a disease often spell bad news. Mutations in over 25 genes, for example, are associated with amyotrophic lateral sclerosis, or ALS, and they all increase the risk of developing this incurable disorder. ...
Mar 31, 2022
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An international team of researchers has developed a way to replace almost all of the microglia cells in a mouse brain using circulation-derived myeloid cells as a way to treat neurodegenerative disease using a technique ...
Microglia, the immune cells of the brain, are known for eating up unwanted items like germs and debris, much as their counterparts do in the rest of the body. In early childhood, certain microglia remove unneeded connections, ...
Mar 7, 2022
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