A new liquid biopsy test could detect microsatellite instability (MSI) and tumor mutational burden (TMB), indicating that it could help determine which patients are likely to respond to immune checkpoint inhibitors, according ...
Sep 11, 2019
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Not all cancer therapies are successful, but cancer researchers increasingly are able to identify the right treatments for the right patients at the right time. A researcher at the University of Oklahoma has helped lead a ...
Mar 21, 2024
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A study at The University of Texas MD Anderson Cancer Center discovered a novel therapeutic vulnerability for patients who have tumors caused by a genetic misfire in the DNA mismatch repair (MMR) pathway, a system for repairing ...
Feb 27, 2020
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In a study published today in Nature Communications, a team of scientists from French-American techbio Owkin and pathology labs in France present a blind validation of MSIntuit CRC, a first-in-class AI-driven digital pathology ...
Nov 7, 2023
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A Massachusetts General Hospital (MGH) research team has used epigenome editing tools to investigate how the genetic abnormality that drives Ewing sarcoma—the second most common bone cancer in children and young adults—unleashes ...
Aug 2, 2018
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Bottom Line: Incorporation of pan-cancer microsatellite instability (MSI) detection into the 74-gene panel Guardant360 liquid biopsy assay showed high concordance with matched tissue samples in nearly 1,000 patients.
Aug 5, 2019
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Genomic profiling of patients who were treated for colorectal cancer at a major U.S. cancer center showed that patients with African ancestry had fewer actionable mutations than patients with European ancestry and were less ...
Apr 17, 2023
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Colorectal cancer (CRC) presents with varying clinical characteristics due to tumor heterogeneity. Microsatellite instability (MSI), present in 10–15% of CRC cases, indicates a different clinical trajectory than microsatellite ...
Dec 15, 2023
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Systemic sclerosis is an autoimmune disorder that is characterized by excess deposition of connective tissue in the skin, lungs, kidneys and vessels, resulting in lung, heart and kidney dysfunction. In a new study, researchers ...
Jul 31, 2020
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Colorectal cancer differs from patient to patient. That is why scientists are looking for characteristic tumor markers that allow them to make predictions about the likely response to certain therapies and the individual ...
May 16, 2024
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