Medical research

Study shows how misfolded proteins are selected for disposal

It's almost axiomatic that misfolded proteins compromise how cells normally function and cause debilitating human disease, but how these proteins are detected and degraded within the body is not well understood. Neurodegenerative ...

Alzheimer's disease & dementia

Age associated with amyloid-beta kinetics

(HealthDay)—Increasing age is associated with slowed amyloid-β (Aβ) turnover, according to a study published online July 20 in the Journal of Neurology.

Diseases, Conditions, Syndromes

iPSC-derived kidney organoids to model a lifelong renal disease

Researchers have generated induced pluripotent stem cell (iPSC)-derived kidney organoids to model Alport syndrome caused by a mutation in the COL4A5 gene and have demonstrated the utility of a chemical chaperone to rescue ...

Medical research

Epidemic spreading and neurodegenerative progression

Researchers from the Montreal Neurological Institute have used a model inspired by patterns of epidemic disease spreading to map how misfolded proteins propagate within the brain.

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