DNA is replicated to pass genetic information to the daughter cells during cell proliferation. Replication errors, if not repaired, can lead to genetic mutations. For an individual organism, some DNA mutations may cause disease, ...
Aug 29, 2016
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Up to 15 percent of colorectal cancers show a genetic mutation known as DNA mismatch repair deficiency, or dMMR. Until now, little has been known about how the mutation behaves in rectal cancer patients, what causes dMMR, ...
Jul 19, 2016
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Scientists from the Institute for Basic Science (IBS) have successfully inhibited the growth of colon tumors in mice with mismatch repair deficiency. The research team, headed by the Center's director MYUNG Kyungjae, made ...
Jun 15, 2016
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Colorectal cancer is the second most common cause of cancer-related deaths in the Western world, mainly because it is usually diagnosed too late. Finding ways to identify those people who are at increased risk of developing ...
May 23, 2016
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Among colorectal cancers, loss of the gene SMAD4 was significantly more common in cancers arising in the hindgut (the left side of the colon to the rectum) than in cancers arising in the midgut (the right side of the colon) ...
Nov 9, 2015
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For women with Lynch syndrome, an association was found between the risk of endometrial cancer and the age of first menstrual cycle, having given birth, and hormonal contraceptive use, according to a study in the July 7 issue ...
Jul 7, 2015
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In a report of a proof-of-principle study of patients with colon and other cancers for whom standard therapies failed, researchers at the Johns Hopkins Kimmel Cancer Center say that mistakes in so-called mismatch repair genes, ...
May 29, 2015
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A study that examined 17 million mutations in the genomes of 650 cancer patients concludes that large differences in mutation rates across the human genome are caused by the DNA repair machinery.
Feb 23, 2015
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A new study involving researchers at The University of Nottingham has revealed how children with an aggressive cancer predisposition syndrome experience a never before seen flood of mutations in their disease in just six ...
Feb 3, 2015
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A unique new study led by University of Kentucky Markey Cancer Center researchers Guo-Min Li and Libya Gu, in collaboration with Dr. Wei Yang at National Institutes of Health, reveals a novel mechanism explaining the previously ...
Apr 25, 2013
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