Genetics
Research on mutation 'hotspots' in DNA could lead to new insights on cancer risks
New research from Indiana University has identified "hotspots" in DNA where the risk for genetic mutations is significantly elevated.
Jul 30, 2018
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Page 3 - News tagged with mismatch repair
Oncology & Cancer
New insights into the origins of mutations in cancer
Researchers at the European Bioinformatics Institute (EMBL-EBI), the University of Dundee and the Wellcome Sanger Institute have used human and worm data to explore the mutational causes of cancer. Their study, published ...
May 1, 2018
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Genetics
Cells rank genes by importance to protect them, according to new research
Researchers at the University of Oxford have discovered that a cellular mechanism preferentially protects plant genes from the damaging effects of mutation.
Jan 5, 2018
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Oncology & Cancer
Use of MMR deficiency testing in younger CRC patients is low
(HealthDay)—Fewer than half of younger adults with colorectal cancer (CRC) undergo mismatch repair (MMR) deficiency of DNA testing, according to a study published online Nov. 9 in JAMA Oncology.
Nov 13, 2017
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Genetics
DNA correction mechanism is more efficient in the most important regions of the genome
A study published by IRB Barcelona in Nature Genetics demonstrates that the error (mutation) surveillance and repair system shows greater efficiency in the protein-coding regions of genes.
Nov 7, 2017
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Oncology & Cancer
Immunotherapy treatment option for selected breast cancer patients, genetic study suggests
Immunotherapy drugs could help some breast cancer patients based on the genetic changes in their tumours, researchers at the Wellcome Trust Sanger Institute and their collaborators find. Published today (13 September) in ...
Sep 13, 2017
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Oncology & Cancer
Biomarkers for identifying tumor aggressiveness
Early-stage colon cancer patients could benefit in the future from specific genetic tests that forecast their prognosis and help them make the right decision regarding chemotherapy. Two of the biomarkers involved are the ...
Jul 26, 2017
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Oncology & Cancer
Flaws in a tumor's genetic mending kit drive treatment response to immunotherapy
In an expanded, three-year clinical trial of 86 patients with colorectal and 11 other kinds of cancer that have so-called 'mismatch repair' genetic defects, scientists at Johns Hopkins Medicine and its Bloomberg~Kimmel Institute ...
Jun 9, 2017
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Oncology & Cancer
FDA approves cancer drug for personalized immunotherapy approach
Earlier this week, for the first time, a drug was FDA-approved for cancer based on disease genetics rather than type.
May 26, 2017
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Oncology & Cancer
A counterintuitive finding that could benefit younger colorectal cancer patients
Younger colon cancer patients appear to have more than three times as many mutations in their tumors as older patients, which could lead to more effective treatment decisions, say researchers at Georgetown Lombardi Comprehensive ...
May 17, 2017
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