Genetics

New mutations accumulate in reproductive cells of older mice

Older mice have more new mutations—changes in DNA sequence that occur in the individual rather than being inherited from a parent—than younger mice in the genomes of their mitochondria, according to researchers at Penn ...

Medical research

A new blood component revealed

Does the blood we thought to know so well contain elements that had been undetectable until now? The answer is yes, according to a team of researchers from Inserm, Université de Montpellier and the Montpellier Cancer Institute ...

Genetics

Researchers uncover the genomics of health

Most diseases have a genetic component. To better understand disease, researchers led by the Garvan Institute of Medical Research are analysing genetic information to determine what keeps us healthy.

Genetics

Gene regulation linked to energy production

Researchers at The University of Western Australia, Harry Perkins Institute of Medical Research and Curtin University have made a fundamental discovery about of the regulation of genes in mitochondria, providing a new insight ...

Medical research

Increasing food intake by swapping mitochondrial genomes

Many of the characteristics that make people so different from each other are often the result of small differences in the DNA between individuals. Variation in just a single base in our DNA can cause significant variation ...

Genetics

3-parent IVF could prevent illness in many children

Mitochondrial donation is an assisted reproductive technology sometimes described as "three-parent IVF". It's designed for women at high risk of passing on faulty mitochondrial DNA and having a child with severe mitochondrial ...

Medical research

New study challenges our understanding of premature ageing

Disturbances in the function of mitochondrial DNA can accelerate the ageing process in ways that are different than previously thought, according to a new Finnish study published in Nature Metabolism. Offering a new perspective ...

Medications

Potential drug targets for ALS and FTD identified in two studies

A pair of collaborative studies led by Fen-Biao Gao, Ph.D., have identified two potential drug targets for the diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The studies, which appear in Nature ...

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