Oncology & Cancer

Boosting the immune response against cancer

T cells are usually good at eliminating diseased cells, but they seem to fail when it comes to tumor cells. In JCI Insight, MDC teams led by Armin Rehm and Uta Höpken describe what inhibits this immune function, and how ...

Overweight & Obesity

An important step towards fasting-based therapies

Previous studies have shown how fasting can influence the immune system to improve different chronic inflammatory conditions, but little is known about how immune responses might determine a healthy metabolism. Since the ...

Vaccination

Emerging protein-based COVID-19 vaccines could be game-changing

Current messenger RNA vaccines appear to offer at least some protection against new SARS-CoV-2 variants, including omicron, especially for people who have received boosters. But manufacturing costs and the need for ultra-cold ...

Pediatrics

Biosensors transform the diagnosis of infections in newborns

Sepsis refers to a systemic (body-wide) infection accompanied by inflammation. Newborn infants are particularly susceptible to developing sepsis, given their naïve and under-developed immune systems. The infant immune system ...

Genetics

Gene changes might explain long-haul COVID-19 symptoms

Results from a new cell study suggest that the SARS-CoV-2 spike protein can bring about long-term gene expression changes. The findings could help explain why some COVID-19 patients—referred to as COVID long-haulers—experience ...

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