Diseases, Conditions, Syndromes

Study links patrolling monocytes to lupus-related kidney disease

A study led by St. Jude Children's Research Hospital has found evidence suggesting that patrolling monocytes may drive glomerulonephritis, inflammation of the kidneys, in patients with lupus. The findings overturn the previously ...

Oncology & Cancer

Programming white blood cells to fight pancreatic cancer

Pancreatic cancer is the third most lethal cancer in the United States. Patients typically don't know they have it until it's too late, making it difficult to treat. Only 9 percent survive five years after diagnosis.

Medical research

Researchers hope to be able to replace dysfunctional brain cells

A new study by researchers at Karolinska Institutet supports the theory that replacement of dysfunctional immune cells in the brain has therapeutic potential for neurodegenerative diseases like ALS and Alzheimer's disease. ...

Cardiology

Stretch, inflammation and hypertension

Monocytes are known to play an important role in hypertension, although the exact mechanism remains unclear. It is hypothesized that a potential source of monocyte activation originates from its interaction with the vascular ...

Oncology & Cancer

By forming clots in tumors, immune cell aids lung cancer's spread

University of North Carolina Lineberger Comprehensive Cancer Center researchers have found that by helping to form clots within tumors, immune cells that flock to a particular type of lung cancer are actually building a foundation ...

Immunology

Colon signaling pathway key to inflammatory bowel disease

The intestine encounters more foreign substances and potential toxins than other parts of the body, so it is not surprising that a healthy gut is maintained by the tight control of immune responses. These protect against ...

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Monocyte

Monocytes are a type of white blood cell and are part of the innate immune system of vertebrates including all mammals (including humans), birds, reptiles, and fish. Monocytes play multiple roles in immune function. Such roles include: (1) replenish resident macrophages and dendritic cells under normal states, and (2) in response to inflammation signals, monocytes can move quickly (approx. 8-12 hours) to sites of infection in the tissues and divide/differentiate into macrophages and dendritic cells to elicit an immune response. Half of them are stored in the spleen. Monocytes are usually identified in stained smears by their large kidney shaped or notched nucleus.

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