Obstetrics & gynaecology

Study reveals genetic differences among fetal monocytes

A multidisciplinary team of Northwestern Medicine investigators has discovered striking differences in gene expression of monocytes—specialized immune cells—in the developing fetus, according to findings published in ...

Immunology

How COVID-19 triggers massive inflammation

A study led by researchers at Boston Children's Hospital explains for the first time why COVID-19 causes severe inflammation in some people, leading to acute respiratory distress and multi-organ damage. Surprisingly, the ...

Diseases, Conditions, Syndromes

Research suggests new way to detect, monitor lung diseases

New lung research from an international team of scientists could offer doctors a new way to detect and monitor progressive lung diseases—and may also shed light on the fundamental causes of those conditions.

Diseases, Conditions, Syndromes

Partial bone marrow transplant 'rescues' mice with cystic fibrosis

Scientists at La Jolla Institute for Immunology (LJI) have found they can dramatically improve survival of mice with cystic fibrosis through a partial bone marrow transplant. Their new study in the Journal of Immunology shows ...

Immunology

Gene editing expands to new types of immune cells

In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) ...

Oncology & Cancer

An antibody-drug combo to combat cancer

Leukemias are debilitating cancers of the hematopoietic or blood-forming cells of the bone marrow. Now, researchers at Tokyo Medical and Dental University (TMDU) describe an ingenious strategy against chronic myelomonocytic ...

Medical research

New study on the role of monocytes in sarcoidosis

The cause of the inflammatory lung disease sarcoidosis is unknown. In a new study, researchers at Karolinska Institutet have investigated whether a type of immune cell called a monocyte could be a key player in sarcoidosis ...

Immunology

New insights into the control of inflammation

Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. ...

Immunology

New research may explain severe virus attacks on the lungs

In some cases, immune cells in the lungs can contribute to worsening a virus attack. In a new study, researchers at Karolinska Institutet in Sweden describe how immune cells called macrophages develop in the lungs and which ...

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Monocyte

Monocytes are a type of white blood cell and are part of the innate immune system of vertebrates including all mammals (including humans), birds, reptiles, and fish. Monocytes play multiple roles in immune function. Such roles include: (1) replenish resident macrophages and dendritic cells under normal states, and (2) in response to inflammation signals, monocytes can move quickly (approx. 8-12 hours) to sites of infection in the tissues and divide/differentiate into macrophages and dendritic cells to elicit an immune response. Half of them are stored in the spleen. Monocytes are usually identified in stained smears by their large kidney shaped or notched nucleus.

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