The heart can stably maintain blood flow—at rest or under stress—over a lifetime. Using a mouse model, an LMU team has now uncovered the role played by a specific class of ion channels in controlling the heart rate.
Nov 3, 2020
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Scientists across the globe often use mouse models in the study of human conditions to advance the pursuit of medicines and treatments. Now, Johns Hopkins Medicine researchers and their collaborators have created and characterized ...
Aug 18, 2020
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A receptor that plays an essential role in safely clearing chronic unresolved cardiac inflammation may offer new targets for treating an increasing type of heart failure associated with age-related obesity, suggests a preclinical ...
Jun 22, 2020
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Many heart diseases are linked to oxidative stress, an overabundance of reactive oxygen species. The body reacts to reduce oxidative stress—where the redox teeter-totter has gone too far up—through production of endogenous ...
May 14, 2020
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Researchers trying to turn off a gene that allows cancers to spread have made a surprising U-turn. By making the gene overactive and functional in the hearts of mice, they have triggered heart cell regeneration. Since adult ...
Apr 14, 2020
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209
Barth syndrome is a rare metabolic disease in boys caused by mutation of a gene called tafazzin or TAZ. It can cause life-threatening heart failure and also weakens the skeletal muscles, undercuts the immune response, and ...
Mar 9, 2020
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Roughly 80% of people with myotonic dystrophy—a common form of muscular dystrophy—experience dangerous heart ailments, and heart rhythm defects are the second-leading cause of death in those with the condition. In a new ...
Feb 27, 2020
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New research from North Carolina State University shows that platelet microparticles are an effective way to deliver therapeutic drugs directly to the heart following a heart attack. This method increases drug concentration ...
Feb 5, 2020
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After heart attack injury, several fatty-acid-derived bioactive molecules—including one called resolvin D1—play an essential signaling role to safely clear inflammation and help repair heart muscle. The mechanism of how ...
Nov 20, 2019
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An unexplored kinase in heart muscle cells may be a good target to treat heart failure, a disease that is only incrementally delayed by existing therapies. Failing human hearts showed reduced amounts of this kinase, and preclinical ...
Oct 31, 2019
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