Fentanyl, a mu-opioid receptor agonist, is one of the most commonly used analgesics in hospitals, and may induce long-lasting behavioral and somatosensory impairment in rodents. However, whether the use of fentanyl is associated ...
Jun 14, 2022
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A targeted opioid that only treats diseased tissues and spares healthy tissues relieves pain from inflammatory bowel disease without causing side effects, according to new research published in the journal Gut.
Mar 31, 2021
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With the support of the National Institute on Drug Abuse, scientists at Wake Forest School of Medicine have been working to find a safe, non-addictive pain killer to help fight the current opioid crisis in this country.
Aug 29, 2018
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At a hearing on Capitol Hill earlier this year, U.S. Senator Lamar Alexander asked an important question: Why is most of the treatment for opioid addiction more opioids?
Jun 27, 2018
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The problem with opioids is that they kill pain – and people. In the past three years, more than 125,000 persons died from an opioid overdose – an average of 115 people per day – exceeding the number killed in car accidents ...
Jun 21, 2018
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For the first time, scientists at the University of North Carolina School of Medicine and collaborators solved the crystal structure of the activated kappa opioid receptor bound to a morphine derivative. They then created ...
Jan 4, 2018
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(HealthDay)—Electroacupuncture (EA) can alleviate hyperalgesia during ethanol withdrawal, and this effect may involve mu opioid receptors (MORs) in the habenula, according to an experimental study published online Feb. ...
Feb 8, 2017
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A commercially available drug may help drastically reduce two side effects of opioid painkillers—a growing tolerance and a paradoxical increased sensitivity to pain—without affecting the drugs' ability to reduce pain, ...
Jan 17, 2017
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A study of advanced cancer patients published in the journal Annals of Oncology and presented at this year's World Congress of Anaesthesiologists in Hong Kong suggests that opioid painkillers and their receptor in cells - ...
Sep 1, 2016
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Investigators at the Stanford University School of Medicine and their collaborators at three other institutions have identified a novel compound that appears to exhibit painkilling power comparable to morphine but lacks that ...
Aug 17, 2016
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