Inflammatory disorders

Targeting necroptosis for inflammatory myopathies

A new study has suggested that treatment to target necroptosis in muscle fibers using a necroptosis inhibitor lessens myositis-induced muscle weakness as well as muscle cell death and inflammation in the muscles. This has ...

Medical research

International team advances research on muscle health

An international team, led by University of Ottawa Faculty of Medicine researchers, has published findings that could contribute to future therapeutics for muscle degeneration due to old age, and diseases such as cancer and ...

Cardiology

Simultaneous optical and electrical tracking of heart activity

It is still elusive to what extent interactions between different cell types of the heart influence the normal heart rhythm and possibly trigger life-threatening arrhythmias. A new measurement method developed at the University ...

Medical research

Muscling up with nanoparticle-based anti-inflammatory therapy

Muscular dystrophies are a group of genetic diseases that lead to the progressive loss of muscle mass and function in patients, with the incurable Duchenne Muscular Dystrophy (DMD), which affects all the body's muscles, primarily ...

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Skeletal muscle

Skeletal muscle is a form of striated muscle tissue existing under control of the somatic nervous system. It is one of three major muscle types, the others being cardiac and smooth muscle. As its name suggests, skeletal muscle is linked to bone by bundles of collagen fibers known as tendons.

Skeletal muscle is made up of individual components known as muscle fibers. These fibers are long, cylindrical, multinucleated cells composed of actin and myosin myofibrils repeated as a sarcomere, the basic functional unit of the cell and responsible for skeletal muscle's striated appearance and forming the basic machinery necessary for muscle contraction. The term muscle refers to multiple bundles of muscle fibers held together by connective tissue.

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