Genetics
COVID-19 mutations and their links to excessive immune responses
Mutations on a key SARS-CoV-2 viral protein are linked to extreme immune responses and could offer a novel vaccine target.
Sep 27, 2023
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Page 3 - News tagged with mutated protein
Neuroscience
Researchers identify key steps to toxic protein accumulation in Alzheimer's and other diseases
Under normal circumstances, tau protein is part of the brain's infrastructure, important for stabilizing neurons into their proper shapes. But sometimes tau gets knotted up into tangles and turns toxic, injuring brain tissue ...
Sep 21, 2023
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Neuroscience
How a molecule deletes neural chatter might help treat Angelman syndrome
Researchers from the University of Tokyo reveal how the presynaptic Ube3a E3 ligase, a causal factor in Angelman syndrome, eliminates neural chatter. The study helps find a better drug target for the Angelman syndrome treatment.
Sep 14, 2023
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Genetics
New insights into the development of Parkinson's disease in the brain might open the doors to new therapies
Parkinson's disease, characterized by various motor dysfunctions, is the second most common neurodegenerative disorder in the world. It is known that specific gene mutations that are passed down through families are responsible ...
Sep 11, 2023
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Medical research
Loss of a particular protein causes growth defects in mice and humans
Through next-generation sequencing, investigators have identified a mutation in the TMCO3 gene in two sisters with short stature.
Aug 9, 2023
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Oncology & Cancer
RNA stability may play a role in prostate cancer
Mutations in a genetic region that regulates RNA stability could influence prostate cancer outcomes and drug resistance, according to new work from scientists at Fred Hutchinson Cancer Center published in Cell Reports.
Aug 7, 2023
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Genetics
Researcher identifies key mechanism in Parkinson's disease
Yulan Xiong, assistant professor of neuroscience at UConn Health, and her team have discovered that a regulator compound holds the potential to treat Parkinson's disease.
Aug 1, 2023
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Medical research
Improperly processed genetic material in Fragile X syndrome—correctly cutting RNA offers a potential treatment
Fragile X syndrome is a genetic disorder caused by a mutation in a gene that lies at the tip of the X chromosome. It is linked to autism spectrum disorders. People with fragile X experience a range of symptoms that include ...
Jul 27, 2023
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Genetics
How a genetic mutation can cause individuals with normal cholesterol to develop heart disease at a young age
A novel molecular pathway to explain how a mutation in the gene ACTA2 can cause individuals in their 30s—with normal cholesterol levels and no other risk factors—to develop coronary artery disease has been identified, ...
Jul 7, 2023
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Oncology & Cancer
Researchers target mutation that leads to pancreatic cancer
After 30 years of discouraging results in attempting to develop drugs to inhibit a mutated protein associated with some of the more challenging cancers to treat, research on RAS proteins is booming.
Jul 7, 2023
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