Oncology & Cancer

Spread of breast cancer reduced by targeting acid metabolite

It's a metabolite found in essentially all our cells that, like so many things, cancer overexpresses. Now scientists have shown that when they inhibit 20-HETE, it reduces both the size of a breast cancer tumor and its ability ...

Oncology & Cancer

Combination immunotherapy effective for advanced prostate cancer

Advanced prostate cancer resistant to castration therapy appears to respond well to a combination of immune checkpoint blockades and treatments that target certain immune-busting cells commonly associated with poor patient ...

Oncology & Cancer

Nixing the cells that nix immune response against cancer

Some cells excite the immune system. Others soothe it. Myeloid-derived suppressor cells (MDSCs) are one type of soothing cell, and previous work shows that cancer may specifically boost production of MDSCs as a way to tamp ...

Immunology

Can myeloid derived suppressor cells subdue viral infections?

Myeloid derived suppressor cells (MDSCs), produced in the bone marrow as part of the human immune response to a tumor, may have a potent immunoregulatory role following viral infection. The similarities and differences between ...

Oncology & Cancer

Mechanism of an effective MEK inhibitor identified

Understanding the effects of certain targeted therapies on antitumor immunity is necessary to design combined interventions for more effective cancer treatment. In the past, data have shown that trametinib, an FDA-approved ...

Oncology & Cancer

Anti-cancer effects found in natural compound derived from onions

Research from Kumamoto University, Japan finds that a natural compound isolated from onions, onionin A (ONA), has several anti-cancer properties for ovarian cancer. This discovery is a result of research on the effects of ...

Diseases, Conditions, Syndromes

Immune cells as biomarkers for idiopathic pulmonary fibrosis

Researchers at Helmholtz Zentrum M√ľnchen, a partner in the German Center for Lung Research (DZL), have discovered that the number of myeloid-derived suppressor cells (MDSC) is increased in the blood of patients with idiopathic ...

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