Medications

Over-the-counter Narcan: A big win for public health

Narcan, the naloxone nasal spray used to reverse opioid overdose, was approved Wednesday for over-the-counter sale by the Food and Drug Administration. It's a major victory for harm-reduction advocates and public health professionals—and ...

Medications

Expert discusses FDA approval of OTC naloxone

The Food and Drug Administration has approved a recommendation that naloxone, the opioid overdose reversal drug commonly known as Narcan, be made available over the counter without a prescription.

Medical research

Marijuana-derived compounds could reverse opioid overdoses

There's been a recent push in the U.S. to make naloxone—a fast-acting opioid antidote—available without a prescription. This medication has saved lives, but it's less effective against powerful synthetic opioids, such ...

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Naloxone

Naloxone is an opioid antagonist drug developed by Sankyo in the 1960s. Naloxone is a drug used to counter the effects of opiate overdose, for example heroin or morphine overdose. Naloxone is specifically used to counteract life-threatening depression of the central nervous system and respiratory system. Naloxone is also experimentally used in the treatment for congenital insensitivity to pain with anhidrosis (CIPA), an extremely rare disorder (1 in 125 million) that renders one unable to feel pain. It is marketed under various trademarks including Narcan, Nalone, and Narcanti, and has sometimes been mistakenly called "naltrexate." It is not to be confused with naltrexone, an opioid receptor antagonist with qualitatively different effects, used for dependence treatment rather than emergency overdose treatment.

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