In a new study, researchers at Karolinska Institutet show that the activation of specific cell surface proteins—cortisol, estrogen and vitamin A—in mice with human neuroblastoma cells results in the neuronal differentiation ...
Jul 25, 2022
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Cancer Research UK doctors have launched a new trial which offers a new type of molecular radiotherapy - never before tested in children - for one of the deadliest childhood cancers.
Jan 30, 2014
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The cancer-causing form of the gene Myc alters the metabolism of mitochondria, the cell's powerhouse, making it dependent on the amino acid glutamine for survival. In fact, 40 percent of all "hard-to-treat" cancers have a ...
Nov 13, 2012
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A Ludwig Cancer Research study has identified in neuroblastoma tumors a potential vulnerability that might be exploited to improve treatment of the aggressive childhood cancer, which accounts for roughly 15% of all deaths ...
Feb 7, 2022
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Children who suffer a relapse of the aggressive cancer known as neuroblastoma have small chances of survival. However, a group including researchers at Karolinska Institutet in Sweden have now shown that DHODH blockers, which ...
Aug 22, 2022
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Children with high-risk neuroblastoma whose treatment included two autologous stem-cell transplants were more likely to be free of cancer three years later than patients who underwent a single transplant, a Phase 3 clinical ...
Jun 6, 2016
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Researchers at UCL have developed a new way to deliver drugs that can shut down cancer-promoting mutations in neuroblastoma. The findings in mice, show the method, which uses tiny bubbles to deliver therapies directly to ...
Jul 28, 2021
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A newly developed immunotherapy that simultaneously uses modified immune-fighting cells to home in on and attack two antigens, or foreign substances, on cancer cells was highly effective in mice implanted with human neuroblastoma ...
Sep 23, 2021
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A pair of recent studies suggests that even among patients receiving advanced cancer care, poverty is a predictor of worse outcomes. The disturbing findings raise many questions that follow-up studies are now exploring.
Jan 7, 2021
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A detailed 'atlas' of neuroblastoma tumors points to a new target for immunotherapy. Scientists from the Princess Máxima Center for pediatric oncology in the Netherlands mapped this childhood tumor at the level of individual ...
Jan 4, 2024
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