As outlined in a study published in Developmental Cell, researchers have discovered a novel function for p27 in the control of interneuron migration in the developing cerebral cortex.
Oct 2, 2012
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Promoting the signaling pathway of reelin, an essential extracellular protein for the neuronal migration and synaptic plasticity, could be an effective therapeutic strategy to counterbalance the main cognitive, biochemical ...
Jan 23, 2020
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Over a hundred years after the discovery of the neuron by neuroanatomist Santiago Ramón y Cajal, scientists continue to deepen their knowledge of the brain and its development.
Apr 19, 2023
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Mutations in single genes can cause catastrophic diseases, such as Huntington's Disease or sickle cell anemia. However, many conditions, including cancer, diabetes and birth defects are multigenic, arising from the collective ...
Jan 31, 2013
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The zebrafish, a tropical freshwater fish similar to a minnow and native to the southeastern Himalayan region, is well established as a key tool for researchers studying human diseases, including brain disorders. Using zebrafish, ...
Feb 18, 2014
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Neurons are not randomly arranged in the human brain. In the cortex, they are organized in interconnected clusters with high intrinsic connectivity. This modular connectivity structure, in which clusters eventually serve ...
Oct 9, 2019
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The structure and functions of the tip of migrating neurons remain elusive. A research group has found that the PTPσ-expressing growth cone senses the extracellular matrix and drives neuronal migration in the injured brain, ...
Mar 11, 2024
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