Rafal Ciosk and his group at the FMI have identified an important link between the Notch signaling pathway and PRC2-mediated gene silencing. They showed that a fine balance between epigenetic silencing and signaling is crucial ...
Sep 23, 2016
0
1
A new study by Johns Hopkins researchers links a well-known cell communication pathway called Notch to one of the most common—but overall still rare—brain tumors found in children.
Feb 6, 2015
0
5
A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice.
Sep 27, 2023
0
8
Hematopoietic stem cells (HSCs) give rise to all other blood cell types, but their development and how their fate is determined has long remained a mystery. In a paper published online this week in Nature, researchers at ...
Aug 14, 2014
0
0
Researchers in Germany have discovered that colon cancers are often resistant to existing drug treatments because they are composed of two different cell types that can replace each other when one cell type is killed. The ...
May 16, 2018
0
7
Notch genes are a double-edged sword: in some cancers they have a harmful effect because they promote tumour growth, whilst in others they act as tumour suppressors. The reason is still unclear, making it impossible to predict ...
Jan 12, 2015
0
16
EPFL spin-off Cellestia Biotech has just been given the regulatory go-ahead to start clinical testing a molecule it has developed to treat cancers involving mutations of the Notch gene. The molecule is a ray of hope for the ...
Sep 1, 2017
0
2
New fundamental knowledge about the regulation of stem cells in the nerve tissue of zebrafish embryos results in surprising insights into neurodegenerative disease processes in the human brain. A new study by scientists at ...
Aug 19, 2014
0
0
Nestled deep within the body, the epithelial lining of the respiratory system is nonetheless seriously exposed. Its direct contact with environmental air necessitates protective mechanisms that both seal off the respiratory ...
Jan 22, 2013
0
0
Dissecting the mechanisms implicated in cell architecture should provide new insights for understanding development and tissue morphogenesis in general. An European study focused on the role of the Notch signalling pathway ...
Oct 5, 2012
0
0
