With a series of new grants, Saint Louis University researchers will tackle the twin epidemics of diabetes and obesity by tapping into the potential of two nuclear receptors that control muscle metabolism. The scientists ...
Mar 23, 2017
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In a paper published in Biochemical Pharmacology, Saint Louis University researchers examined the way a nuclear receptor called REV-ERB is involved in regulating cholesterol metabolism. Their findings suggest that drugs targeting ...
Mar 7, 2017
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A research team has studied for the first time the 3-D structure of the homodimeric androgen receptor ligand-binding domain, a structure that eluded researchers for years. This new structure of the nuclear receptor explains ...
Feb 7, 2017
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Malignant neuroendocrine tumors (NETs) are relatively rare, notoriously difficult to treat, and associated with poor long-term survival. According to research presented at the 2016 Annual Meeting of the Society of Nuclear ...
Jun 13, 2016
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(Medical Xpress)—Multiple sclerosis (MS) is an autoimmune inflammatory disorder in which the immune system attacks the myelin sheath enveloping and insulating the nerves. A progressive disease that often results in severe ...
In real estate, location is key. It now seems the same concept holds true when it comes to stopping pain.
Feb 3, 2016
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Multiple sclerosis patients continually lose the insulating myelin sheath that wraps around neurons and increases the speed of impulses in the central nervous system. Whenever neurons are demyelinated, OPCs migrate toward ...
Dec 7, 2015
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On Monday 7 December the journal Nature Communications published the research findings of TU/e, Merck Research Laboratories and Leiden University concerning an entirely new way of antagonizing a human nuclear receptor. The ...
Dec 7, 2015
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Imagine if you could carry a credit card-size record of all the 3 billion A's, T's C's, and G's that make up the alphabet soup of your genome. A simple swipe of the card could inform your physician right away if a drug being ...
Jul 12, 2015
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In new research published in Endocrinology, Thomas Burris, Ph.D., chair of pharmacological and physiological science at Saint Louis University, reports that his team has found a way to prevent type I diabetes in an animal ...
Jan 20, 2015
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