Presence of the genetic mutation BRAF V600E was significantly associated with increased cancer-related death among patients with papillary thyroid cancer (PTC); however, because overall mortality in PTC is low and the association ...
Apr 9, 2013
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Cancer is a complex disease, in which cells undergo a series of alterations, including changes in their architecture; an increase in their ability to divide, to survive and to invade new tissues or metastasis. A category ...
May 6, 2013
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Cancer only arises if two or more genes are mutated. Learning which combinations of mutations cause cancer represents an extremely laborious endeavor. In the current issue of the journal Nature Methods Robert Eferl and colleagues ...
Aug 6, 2012
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In a study published in the scientific journal Oncotarget, researchers from Uppsala University show how the protein EZH2 affects the development of multiple myeloma, and that inhibition of EZH2 could be used as a new strategy ...
Jan 12, 2017
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In a study to investigate how transplanted islet cells can differentiate and mature into insulin-producing pancreatic cells, a team of Japanese researchers found that using a specific set of transcription factors (proteins ...
Sep 25, 2012
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While the mutated KRAS oncogene is associated with many cancers, it has not yet been successfully targeted by a therapeutic agent. Scientists are trying to find another way to target the gene by blocking signals from another ...
May 28, 2013
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An animal study conducted by researchers at Georgetown Lombardi Comprehensive Cancer Center raises questions about the consequences of diet—specifically glucose, the plant-based sugar that fuels cell life—on increased ...
Nov 15, 2012
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Molecular analysis of a tumor biopsy from a proto-oncogene 1 receptor tyrosine kinase positive (ROS1+) patient with acquired crizotinib resistance revealed a novel mutation in the v-kit Hardy Zuckerman 4 feline sarcoma viral ...
Apr 11, 2016
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The c-Fos oncogene has traditionally been linked to cellular activities related to cancer, such as cell division, differentiation—conversion from one cell type to another—or survival. Any alteration of these activities ...
Sep 27, 2013
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Molecular driven therapeutic targets have resulted in a paradigm shift in the treatment of advanced lung adenocarcinoma. However, in early non-small cell lung cancer (NSCLC), surgical resection remains the treatment of choice ...
Mar 22, 2013
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