Opioid abuse is a growing public health crisis, affecting up to 36 million people worldwide. Many of these individuals first get hooked on prescription painkillers that target mu opioid receptors in the brain. A study in ...
Aug 25, 2016
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Investigators at the Stanford University School of Medicine and their collaborators at three other institutions have identified a novel compound that appears to exhibit painkilling power comparable to morphine but lacks that ...
Aug 17, 2016
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Peptide based drug candidates are being discovered at an increasingly rapid pace as therapeutics for many diseases and pain management. . For decades the opioid receptors have been an attractive therapeutic target for pain ...
Jul 13, 2016
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Infertility has become a major medical and social problem worldwide and due in part to male infertility. Yet the molecular mechanisms involved in spermatogenesis are only now beginning to emerge. A piece of research led by ...
Jun 9, 2016
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In a multicenter, randomized clinical trial, ex-prisoners who received six monthly injections of naltrexone—a long-acting medication that blocks opioid receptors in the brain—were significantly less likely to resume opioid ...
Mar 30, 2016
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University of North Carolina researchers uncovered a cellular mechanism by which kappa opioid receptors (KOR) drive anxiety. These proteins inhibit the release of the neurotransmitter glutamate in a part of the brain that ...
Mar 17, 2016
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Currently available evidence from randomized controlled trials (RCT) does not support the use of nalmefene for harm reduction for people with alcohol dependence, according to a systematic review and meta-analysis (SRMA) published ...
Dec 22, 2015
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Researchers at Aalto University and University of Turku have revealed how obesity surgery recovers opioid neurotransmission in the brain.
Oct 13, 2015
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If you have an itch, you have to scratch it. But that's a problem for people with a condition called "chronic intractable itch," where that itchy sensation never goes away—a difficult-to-treat condition closely associated ...
Sep 28, 2015
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A*STAR researchers have found that specialized skin receptors associated with sensing pain also loosen the bonds between cells in skin wounds, enhancing the cells' ability to move into the wound and accelerate the healing ...
Sep 25, 2015
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