Genetics

Probing the genes that organize early brain development

When brains begin developing, there are a lot of moving parts—and when mutations happen in early neurodevelopment, it can lead to disorders like macrocephaly and autism. But scientists don't know much about the ways that ...

Medical research

In vitro organ model research trends

Two distinct approaches are predominantly used to recapitulate physiologically relevant in vitro human organ models. Organoids use stem cells to grow self-assembled replica organs through directed differentiation, whereas ...

Oncology & Cancer

Brain organoids reveal glioblastoma origins

Glioblastomas are the most aggressive form of brain cancer—they grow and spread rapidly through the brain and are virtually impossible to eradicate, typically leading to death within one or two years of diagnosis. Scientists ...

Oncology & Cancer

Researchers use brain organoids to study pediatric brain tumors

Hundreds of miniature brains were grown in the laboratories of the University of Trento to study the genetic mechanisms responsible for medulloblastoma, the most common brain cancer affecting children. The results of a collaborative ...

Oncology & Cancer

Changing cancer care, one organoid at a time

A patient-specific tumor organoid platform developed by Wake Forest Institute for Regenerative Medicine (WFIRM) researchers and their cancer center colleagues could someday take the guessing game out of immunotherapy treatments. ...

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