Genetics

Decoding cell fate: Key mechanism in stem cell switch identified

Stem cells can differentiate to replace dead and damaged cells. But how do stem cells decide which type of cell to become in a given situation? Using intestinal organoids, the group of Bon-Kyoung Koo at IMBA and the Institute ...

Diseases, Conditions, Syndromes

iPSC-derived kidney organoids to model a lifelong renal disease

Researchers have generated induced pluripotent stem cell (iPSC)-derived kidney organoids to model Alport syndrome caused by a mutation in the COL4A5 gene and have demonstrated the utility of a chemical chaperone to rescue ...

Diseases, Conditions, Syndromes

Lab-grown skin helps unlock secrets of mpox virus infection

Skin organoids offer a powerful platform for drug discovery in the ongoing fight against the virus formerly known as monkeypox. A new model system for studying mpox virus infections in the laboratory is providing valuable ...

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