Medical research

Opioid dependence plays role in chronic pain

The bodies of mammals, including humans, respond to injury by releasing endogenous opioids—compounds that mitigate acute pain. A team of researchers led by those at the University of Kentucky has uncovered groundbreaking ...

Medical research

A new role for sodium in the brain

Researchers at McGill University have found that sodium – the main chemical component in table salt – is a unique "on/off" switch for a major neurotransmitter receptor in the brain. This receptor, known as the kainate ...

Medical research

Study shows potential new therapy for neuropathic pain

An international study led by scientists at McGill University reports, for the first time, that drugs that selectively target the melatonin MT2 receptor represent a novel class of analgesic drugs that could be used to treat ...

Neuroscience

Blunting pain's emotional component

Chronic pain involves more than just hurting. People suffering from pain often experience sadness, depression and lethargy. That's one reason opioids can be so addictive—they not only dampen the pain but also make people ...

Medical research

Discovery suggests route to safer pain medications

Strategies to treat pain without triggering dangerous side effects such as euphoria and addiction have proven elusive. For decades, scientists have attempted to develop drugs that selectively activate one type of opioid receptor ...

Neuroscience

Study shows why some pain drugs become less effective over time

Researchers at the University of Montreal's Sainte-Justine Hospital have identified how neural cells like those in our bodies are able to build up resistance to opioid pain drugs within hours. Humans have known about the ...

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