Medical research

Non-opioid compounds squelch pain without sedation

A newly identified set of molecules alleviated pain in mice while avoiding the sedating affect that limits the use of opiates, according to a new study led by researchers at UC San Francisco. The molecules act on the same ...

Inflammatory disorders

Scientists reveal mechanism for colon pain and inflammation

Researchers at the NYU Pain Research Center have identified a mechanism that underlies inflammation and pain in the colon, and demonstrated that blocking a key receptor from entering colon cells can inhibit inflammation and ...

Medical research

Can a dangerous microbe offer a new way to silence pain?

Anthrax has a scary reputation. Widely known to cause serious lung infections in humans and unsightly, albeit painless, skin lesions in livestock and people, the anthrax bacterium has even been used as a weapon of terror.

Medications

Search for safer pain relief advances with new compounds

Scientists at Scripps Research in Florida have created a collection of new pain-relieving compounds, that like morphine and other drugs, provide relief via activation of opioid receptors, but without inducing many dangerous ...

Medical research

Body's natural pain killers can be enhanced

Fentanyl, oxycodone, morphine—these substances are familiar to many as a source of both pain relief and the cause of a painful epidemic of addiction and death.

Medical research

Research reveals why redheads may have different pain thresholds

New research led by investigators at Massachusetts General Hospital (MGH) provides insights on why people with red hair exhibit altered sensitivity to certain kinds of pain. The findings are published in Science Advances.

Neuroscience

Lipid epoxides target pain, inflammatory pathways in neurons

When modified using a process known as epoxidation, two naturally occurring lipids are converted into potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways that promote pain and inflammation, ...

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