Neuroscience

Researchers gain new insights into pain signaling in the brain

Fast communication between our brain cells—or neurotransmission as it is called—is hugely important for our brain to work properly. Some of the messengers involved in this form of communication are neuropeptides, which ...

Neuroscience

Blunting pain's emotional component

Chronic pain involves more than just hurting. People suffering from pain often experience sadness, depression and lethargy. That's one reason opioids can be so addictive—they not only dampen the pain but also make people ...

Neuroscience

Non-opioid drug relieves pain in mice, targets immune cells

Faced with the epidemic of opioid addiction, researchers have been charged with finding other strategies to treat pain. Their efforts largely have focused on nerve cells that transmit pain signals to the spinal cord and brain. ...

Medications

Pain relief at a lower opioid dose

A team of researchers at Johns Hopkins have found that activating nerve cell receptors along two chemical pathways—one that has previously been linked to how the brain senses "itch"—may improve pain relief when combined ...

Neuroscience

Researchers identify new target for chronic pain

Proteins must be in the right place at the right time in the cell to function correctly. This is even more critical in a neuron than in other cells because of its complex tree-like structure and its function. Researchers ...

Medical research

Researchers develop game changing strategy for pain relief

Researchers from Monash University have developed a new drug delivery strategy able to block pain within the nerve cells, in what could be a major development of an immediate and long lasting treatment for pain.

Medical research

The Big Pore Theory could cure chronic pain

Cornell University researchers have produced for the first time an image of P2X7, a receptor associated with chronic pain. Visualizing the shape of the receptor has also allowed them to make a second groundbreaking discovery: ...

Medications

Researchers identify source of opioids' side effects

A commercially available drug may help drastically reduce two side effects of opioid painkillers—a growing tolerance and a paradoxical increased sensitivity to pain—without affecting the drugs' ability to reduce pain, ...

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