Neuroscience

Research reveals how sleep disruption can exacerbate pain

People often experience headaches and body pain after a lack of sleep, but the mechanisms behind this phenomenon are unclear. A new study led by investigators at Massachusetts General Hospital (MGH), a founding member of ...

Diseases, Conditions, Syndromes

Researchers find genetic cause of Raynaud's phenomenon

Researchers at Queen Mary University of London's Precision Healthcare Research Institute (PHURI) and the Berlin Institute of Health (BIH) at Charité—Universitätsmedizin Berlin have identified the genetic causes of Raynaud's ...

Medical research

Researchers modify drug to enter cells and treat pain

Altering the chemical properties of an anti-nausea drug enables it to enter an interior compartment of the cell and provide long-lasting pain relief, according to a new study led by researchers at NYU College of Dentistry's ...

Medical research

Discovery suggests route to safer pain medications

Strategies to treat pain without triggering dangerous side effects such as euphoria and addiction have proven elusive. For decades, scientists have attempted to develop drugs that selectively activate one type of opioid receptor ...

Medications

How AI can help design drugs to treat opioid addiction

Approximately three million Americans suffer from opioid use disorder, and every year more than 80,000 Americans die from overdoses. Opioid drugs, such as heroin, fentanyl, oxycodone and morphine, activate opioid receptors. ...

Medications

New drug target to treat pain from visceral organs

An approved drug for chronic constipation also relieves the pain associated with that condition. New research by Scott Waldman, MD, Ph.D., chair of pharmacology, physiology and cancer biology at Jefferson, demonstrates that ...

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