Diseases, Conditions, Syndromes

Why do some people hurt more than others?

Anyone who came of age in the 1990s remembers the "Friends" episode where Phoebe and Rachel venture out to get tattoos. Spoiler alert: Rachel gets a tattoo and Phoebe ends up with a black ink dot because she couldn't take ...

Medications

Novel botulinum toxin compound relieves chronic pain

A modified form of botulinum toxin gives long-lasting pain relief in mice without adverse effects and, in time, could replace opioid drugs as a safe and effective way of treating chronic pain, according to research by UCL, ...

Neuroscience

Non-opioid drug relieves pain in mice, targets immune cells

Faced with the epidemic of opioid addiction, researchers have been charged with finding other strategies to treat pain. Their efforts largely have focused on nerve cells that transmit pain signals to the spinal cord and brain. ...

Neuroscience

Mind over matter: Amygdala circuit counteracts pain-driven emotion

Two pathways in the brain converging at the amygdala regulate the anxiety and depression that often accompanies chronic pain, suggests research in male rats published in JNeurosci. One of these pathways may represent a top-down ...

Neuroscience

Molecule may be key to pain relief in diabetic neuropathy

A new study published in the Journal of Clinical Investigation has identified a key molecule that contributes to painful diabetic neuropathy, an incurable nerve disease that affects about one-quarter of all patients with ...

Medications

Scientist searches for alternatives to opioids

Since ancient times, humans have used opium and its derivatives to block pain. Yet in all that time, no one has found a solution to two main side effects of opioids—addiction and overdose.

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