Medical research

Immunotherapy and diabetes—a game of hide and seek?

Immune checkpoint inhibitors (ICIs) are an emerging type of cancer immunotherapy that uses the immune system to attack cancer cells. However, in some patients they cause the immune system to attack healthy cells, leading ...

Genetics

Rare genetic change provides clues to pancreas development

Researchers have discovered a key clue into the development of the pancreas and brain by studying rare patients born without a pancreas. The study from the Wellcome Sanger Institute, the University of Exeter and collaborators ...

Diabetes

Cellular sickness linked to type 1 diabetes onset

A UC San Francisco study of human and mouse pancreatic tissue suggests a new origin story for type 1 (T1) diabetes. The findings flip current assumptions about the causes of the disease on their head and demonstrate a promising ...

Medical research

Weight loss surgery changes the way our bodies sense food

How bariatric surgery helps people with obesity and diabetes is related to changes in the way the gut senses food and nutrients after the operation, researchers report February 5 in the journal Cell Reports. They found that ...

Medical research

Functional insulin-producing cells grown in lab

UC San Francisco researchers have for the first time transformed human stem cells into mature insulin-producing cells, a major breakthrough in the effort to develop a cure for type 1 (T1) diabetes.

Medical research

How type 1 diabetes gradually destroys insulin production

Using the new Imaging Mass Cytometry method, researchers of UZH have investigated the pancreas of healthy organ donors and those with type 1 diabetes. The study shows that many beta cells, which normally produce insulin, ...

Medical research

Next step toward replacement therapy in type 1 diabetes

Scientists have discovered the signals that determine the fate of immature cells in the pancreas. The research shows that they are very mobile and that their destiny is strongly influenced by their immediate environment. ...

Diabetes

Mapping the 100 trillion cells that make up your body

There are about 100 trillion cells that make up the human body. A new megascience endeavor will catalog and image each of the 200 or more types of cells from the 80 known organs and identify the genes that are active in these ...

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