Medical research

Project aims to achieve cell-based heart repair

Chronic heart failure—also known as cardiac insufficiency in medicine—is the most common reason for hospital admissions and one of the most frequent causes of death in the western world. In Germany alone, 4 million people ...

Cardiology

Study finds two protein pathways downregulated in postnatal heart

In work published today in Stem Cell Reports, researchers from the University of Minnesota Medical School discovered two signaling pathways that are downregulated in human hearts after birth. These pathways, mitogen-activated ...

Medical research

How microglia contribute to Alzheimer's disease

One of the hallmarks of Alzheimer's disease is a reduction in the firing of some neurons in the brain, which contributes to the cognitive decline that patients experience. A new study from MIT shows how a type of cells called ...

Oncology & Cancer

Making better, ready-made CAR T cells for cancer immunotherapy

In CAR T-cell immunotherapy, T cells from a patient's own blood are engineered to carry so-called chimeric antigen receptors (CAR) that enhance the T cells' ability to attack and kill tumor cells. While CAR-T therapy is a ...

Neuroscience

Gaining insights into spastic paraplegia

Rare diseases, as the name indicates, only affect a small part of the population. However, for those affected they are particularly challenging, often especially because research into such rare diseases tends to be less of ...

Medical research

Creating an 'adult-like' mature human cardiac tissue

Researchers in the Biomedical Engineering Department at UConn have developed a new cardiac cell-derived platform that closely mimics the human heart, unlocking potential for more thorough preclinical drug development and ...

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Pluripotency

Pluripotency in the broad sense refers to "having more than one potential outcome." In biological systems, this can refer either to cells or to biological compounds. From the Latin pluri=many, potent=power, capacity. A pluripotent cell can create all cell types except for extra embryonic tissue, unlike a totipotent cell, (tot=all), which can produce every cell type including extra embryonic tissue.

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