Medications
Malaria drug treatment breakthrough
An international study, involving researchers from Griffith University's Eskitis Institute, has discovered a molecule which could form the basis of powerful new anti-malaria drugs.
Mar 22, 2013
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Page 2 - News tagged with potent inhibitor
Medications
Computer program narrows drug candidates for treating COVID-19
While vaccination and public education concerning the transmission of the coronavirus causing COVID-19 have been at the forefront of our response to the pandemic, there remains an urgent need for pharmaceutical interventions ...
Mar 24, 2022
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Oncology & Cancer
Cancer therapy may be aided by induced macropinocytosis, a rare form of cell death
In laboratory experiments, a metabolic inhibitor was able to kill a variety of human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route—catastrophic macropinocytosis.
Dec 18, 2019
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Medical research
Inactivation of taste genes causes male sterility
Scientists from the Monell Center report the surprising finding that two proteins involved in oral taste detection also play a crucial role in sperm development.
Jul 1, 2013
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Oncology & Cancer
New mechanism of action for PARP inhibitors discovered
New understanding of how drugs called PARP inhibitors, which have already shown promise for the treatment of women with familial breast and ovarian cancers linked to BRCA mutations, exert their anticancer effects has led ...
Nov 9, 2012
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Oncology & Cancer
ASCO: Case of acquired resistance to crizotinib ID'd
(HealthDay)—A case of acquired resistance to crizotinib has been described in a patient with metastatic lung adenocarcinoma harboring a CD74-ROS1 rearrangement, according to a brief report published online June 1 in the ...
Jun 3, 2013
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Cardiology
Researchers find a possible treatment for one of the main symptoms of premature aging disease
HGPS is a rare genetic disease that affects one in every 4-8 million births. The disease is caused by a spontaneous mutation in one of the two copies (alleles) of the gene LMNA, which codes for lamin A, a protein important ...
Jun 17, 2013
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Oncology & Cancer
Preclinical study indicates potential for novel inhibitor to overcome drug resistance induced by RAF, MEK inhibitors
A new class of investigational medicines may help to treat patients with cancers driven by mutations in genes such as BRAF or KRAS/NRAS, including those patients who have become resistant to therapies that target BRAF directly, ...
Apr 8, 2013
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Oncology & Cancer
Protein in blood exerts natural anti-cancer protection
Researchers from Thomas Jefferson University's Kimmel Cancer Center have discovered that decorin, a naturally occurring protein that circulates in the blood, acts as a potent inhibitor of tumor growth modulating the tumor ...
Jul 2, 2013
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Medications
Pharmacy researcher finds most popular weight-loss drug strongly alters other drug therapies
A University of Rhode Island researcher has discovered that the weight-loss drug orlistat, known by the brand names Xenical and Alli, inhibits a key enzyme that may lead to "severe toxicity of internal organs such as the ...
Dec 10, 2012
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