Two proteins central to the pathology of Alzheimer's disease act as prions—misshapen proteins that spread through tissue like an infection by forcing normal proteins to adopt the same misfolded shape—according to new ...
May 1, 2019
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Yale researchers have identified a drinkable cocktail of designer molecules that interferes with a crucial first step of Alzheimer's and even restores memories in mice, they report Jan. 2 in the journal Cell Reports.
Jan 3, 2019
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A new study in Nucleic Acids Research, published by Oxford University Press, suggests a possible effective treatment strategy for patients suffering from prion disease.
Aug 10, 2020
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Memories in our brains are maintained by connections between neurons called "synapses". But how do these synapses stay strong and keep memories alive for decades? Neuroscientists at the Stowers Institute for Medical Research ...
Jan 27, 2012
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Scientists from the Florida campus of The Scripps Research Institute have identified a single prion protein that causes neuronal death similar to that seen in "mad cow" disease, but is at least 10 times more lethal than larger ...
Feb 9, 2012
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(Medical Xpress) -- Mad cow disease is serious business in the U.K., the human form, known as Creutzfeldt-Jakob after Hans Gerhard Creutzfeldt and Alfons Maria Jakob (CJD), who independently first described its existence ...
A team of scientists who a few years ago identified a major pathway that leads to brain cell death in mice, have now found two drugs that block the pathway and prevent neurodegeneration. The drugs caused minimal side effects ...
Apr 20, 2017
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Research from Eric Kandel's lab at Columbia University Medical Center (CUMC) has uncovered further evidence of a system in the brain that persistently maintains memories for long periods of time. And paradoxically, it works ...
Jul 2, 2015
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There are currently no effective treatments for prion diseases, a family of fatal neurodegenerative conditions caused by accumulations of misfolded copies of a naturally occurring protein. But now, there is finally an effective ...
Nov 6, 2019
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(Medical Xpress) -- Researchers at the University of Wisconsin-Madison and collaborators have discovered a powerful new protein in the eye of the fruit fly that may shed light on blinding diseases and other sensory problems ...
Nov 17, 2011
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More reference expression data
PRNP (PRioN Protein (Creutzfeld-Jakob disease, Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia)) is a gene that codes for a protein called the prion protein (PrP), which is expressed in the brain and several other tissues.
The human PRNP gene is located on the short (p) arm of chromosome 20 between the end (terminus) of the arm and position 12, from base pair 4,615,068 to base pair 4,630,233.
PRNP has also recently been designated CD230 (cluster of differentiation 230).
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