Alzheimer's disease & dementia

Using math to help treat Alzheimer's, Parkinson's and other diseases

Protein aggregation—in which misfolded proteins clump together to form large fibrils—has been implicated in many diseases including Alzheimer's, Parkinson's, and type II diabetes. While the exact role these fibrils play ...

Neuroscience

Tissue model reveals role of blood-brain barrier in Alzheimer's

Beta-amyloid plaques, the protein aggregates that form in the brains of Alzheimer's patients, disrupt many brain functions and can kill neurons. They can also damage the blood-brain barrier—the normally tight border that ...

Medical research

Protein shows promise in treating Parkinson's disease

The true cause of Parkinson's disease is still a mystery to researchers, although they do know that in many patients, a protein called alpha-synuclein (aSyn) tends to aggregate in brain cells. But a different protein could ...

Medical research

Breaking down pathological protein aggregates

ETH researchers have discovered a new mechanism that brain cells use to protect themselves from protein aggregates. Such aggregates play a key role in Parkinson's and other neurodegenerative diseases. This new finding might ...

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