Specific mutations in the protein associated with Parkinson's Disease, in which just one of its 140 building blocks is altered, can make a dramatic difference to processes which may lead to the condition's onset, researchers ...
Aug 29, 2016
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In many neurodegenerative diseases like Parkinson's, protein aggregates form in the brain and are assumed to contribute to neuronal cell death. Yet there exists a cellular defense mechanism that counteracts these aggregates, ...
Nov 11, 2020
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Protein aggregates have been observed in the nerve tissue of patients with Parkinson's disease which consist of individual components (monomers) of the protein α-synuclein which assemble into what are referred to as amyloid ...
Sep 3, 2019
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Researchers have developed a new imaging technique that makes it possible to study why proteins associated with Alzheimer's and Parkinson's diseases may go from harmless to toxic. The technique uses a technology called multi-dimensional ...
Nov 23, 2016
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A newly identified compound is a promising candidate for inhibiting the production of amyloids, the abnormal proteins that form toxic clumps, called fibrils, inside the brains of patients with Alzheimer's disease. As published ...
Feb 3, 2020
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When proteins change their structure and clump together, formation of amyloid fibrils and plaques may occur. Such 'misfolding' and 'protein aggregation' processes damage cells and cause diseases such as Alzheimer's and type ...
Sep 24, 2015
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Alzheimer's disease is a progressive degenerative brain disease most commonly characterized by memory deficits. Loss of memory function, in particular, is known to be caused by neuronal damage arising from the misfolding ...
Jul 12, 2013
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Brain diseases associated with the misformed protein tau, including Alzheimer's disease and frontotemporal lobar degeneration with tau pathologies, are characterized by neurofibrillary tangles (NFTs) comprised of pathological ...
Jan 15, 2013
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Amyloid fibrils play a crucial role in neurodegenerative illnesses. Scientists from Heinrich Heine University Düsseldorf (HHU) and Forschungszentrum Jülich have now been able to use cryo-electron microscopy (cryo-EM) to ...
Aug 21, 2019
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Alzheimer's disease is the leading cause of dementia worldwide and a major cause of disability. Now, researchers at Osaka University and Hokkaido University have shown that repeated precipitation-dissolution events of salt ...
Jul 27, 2020
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