Researchers from Children's Hospital of Philadelphia (CHOP) and Princeton University have discovered a novel genetic disorder associated with neurodevelopmental differences. The discovery identified the disorder in 21 families ...
Apr 26, 2023
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A promising therapy for a range of brain diseases involves antisense oligonucleotides (ASOs)—specialized molecules that can modulate RNA and alter protein production—directly injected into the cerebrospinal fluid, in ...
Mar 13, 2023
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Humans lose brain volume as they age, at an estimated rate of 5% per decade after age 40. But that estimate obscures the role that individual physiology plays in regards to functional brain aging.
Dec 6, 2022
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T cells are a special class of white blood cells that patrol the body and attack infected or foreign tissue. They learn to distinguish friendly proteins from dangerous ones in an organ called the thymus. However, when T cells ...
Aug 2, 2022
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Alzheimer's disease, the most common form of dementia, currently has no cure or effective therapy, in part due to gaps in our understanding of how the progressive neurodegenerative disorder arises in the brain.
Jul 6, 2022
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Sometimes, even the alteration of a single nucleotide in a gene can cause serious disease. In a young boy with epilepsy, this kind of mutation has not just affected the functioning of the protein in question—it could also ...
May 23, 2022
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A new combination of drugs could fix the broken lysosomal enzyme pathway in Parkinson's disease-afflicted brain cells, according to a Northwestern Medicine study published in Neuron.
Nov 24, 2021
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Researchers at UC San Francisco and UC San Diego have mapped out how hundreds of mutations involved in two types of cancer affect the activity of proteins that are the ultimate actors behind the disease. The work points the ...
Sep 30, 2021
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The rhythm in a working heart is regulated by electrical impulses. Disturbances of this bioelectrical process can result in cardiac arrhythmias, or irregularities in heartbeat—a common ailment that can lead to illness and ...
Jul 13, 2021
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Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have shown how RNA-binding proteins modulate synaptic responses that mediate the transmission of nerve cell impulses.
Jun 29, 2021
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