Oncology & Cancer

The long and short of CDK12

Mutations in the BRCA1 and BRCA2 genes pose a serious risk for breast and ovarian cancer because they endanger the genomic stability of a cell by interfering with homologous recombination repair (HR), a key mechanism for ...

Medical research

New mechanism controlling the master cancer regulator uncovered

Who regulates the key regulator? The Research Center for Molecular Medicine of the Austrian Academy of Sciences reports online in the journal Science about a newly discovered mechanism by which RAS proteins, central to cancer ...

Genetics

More than just a DNA repair deficiency syndrome

Cockayne syndrome is a rare hereditary disease that can lead to dwarfism, neurological impairment, premature aging and a shortened life span. Skin symptoms include a striking sensitivity to UV rays and a dramatic loss of ...

Neuroscience

Powerful molecules provide new findings about Huntington's disease

Researchers at Lund University in Sweden have discovered a direct link between the protein aggregation in nerve cells that is typical for neurodegenerative diseases, and the regulation of gene expression in Huntington's disease. ...

Alzheimer's disease & dementia

pH imbalance in brain cells may contribute to Alzheimer's disease

Johns Hopkins Medicine scientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer's disease may be a simple imbalance in acid-alkaline—or pH—chemistry inside ...

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