In the complex chain of molecular events that underlie eating behaviors and body weight, the AMP-activated protein kinase (AMPK) enzyme has proven to be a critical link.
Jul 3, 2012
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Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology reveals how a lipid-converting enzyme helps the cells mobilize these integrins.
Jan 23, 2012
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Researchers at Columbia University Medical Center (CUMC) and collaborators have identified a genetic mutation that causes congenital malformations of the kidney and urinary tract, a common form of birth defect and the most ...
Jul 17, 2013
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Researchers have demonstrated the potential of a new class of drugs for the treatment of refractory chronic obstructive pulmonary disease (COPD). Incurable to date, the disease is one of the most frequent causes of death ...
Jan 15, 2018
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An international public-private research consortium has identified and validated a cellular role of a primary Parkinson's disease drug target, the LRRK2 kinase. This important finding, published in the online, open-access ...
Jan 28, 2016
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A new study indicates that protein kinases, which initiate the process that erodes the body's immunity, significantly contribute to the immunodeficiency in HIV patients. Drugs that block these protein kinases may offer a ...
Mar 1, 2021
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Epileptic seizures often originate in small, localized areas of the brain where neurons abnormally fire in unison. These electrical impulses disrupt proper brain functioning and cause seizures. But what makes regions where ...
Oct 8, 2020
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Some cancer drugs used to treat patients with leukemia may also help stop the Ebola virus and give the body time to control the infection before it turns deadly, US researchers said on Wednesday.
Feb 29, 2012
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Prostate cancer represents a major health challenge and there is currently no effective treatment once it has advanced to the aggressive, metastatic stage. A new has revealed a key cellular mechanism that contributes to aggressive ...
Jul 2, 2019
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Dogs may hold the key to uncovering novel cancer therapy targets and treatments that will benefit domestic animals and their owners, as well as human cancer patients.
Aug 17, 2020
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