Oncology & Cancer
Clearing a path for cancer research
EMBL-EBI researchers have developed a new computational method to study biological signalling networks in healthy and cancer cells.
Sep 10, 2015
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Page 16 - News tagged with protein kinases
Diseases, Conditions, Syndromes
Focus on biological signalling to defeat malaria
Millions of people die each year of malaria – a disease transmitted by the Anopheles mosquito. There are major barriers in vaccine development as well as increased resistance to currently available therapies. New biological ...
Jun 6, 2014
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Oncology & Cancer
Clinical trial delivers good results in leukemia patients
Huntsman Cancer Institute (HCI) researchers Michael Deininger, M.D., Ph.D., and Thomas O'Hare, Ph.D., were part of a team that found a potent oral drug, ponatinib, effective in patients who have developed resistance to standard ...
Nov 30, 2012
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Oncology & Cancer
New kinase detection method helps identify targets for developing cancer drugs
Purdue University researchers have developed a high-throughput method for matching kinases to the proteins they phosphorylate, speeding the ability to identify multiple potential cancer drug targets.
Sep 21, 2017
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Oncology & Cancer
Researchers investigate 59 tumor cell lines
In what is the biggest study of its kind to date, researchers from Technische Universität München (TUM) have identified over 10,000 different proteins in cancer cells. "Nearly all anti-tumor drugs are targeted against cellular ...
Aug 8, 2013
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Medical research
Novel test identifies patients most likely to benefit from ALK inhibition therapy
Approximately one in 20 patients with non-small cell lung carcinoma (NSCLC) has chromosomal aberrations targeting the anaplastic lymphoma kinase (ALK) gene. This has considerable implications for treatment because these patients ...
Dec 12, 2012
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Medical research
Corrected protein structure reveals drug targets for cancer, neurodegenerative diseases
Protein Kinase C (PKC) is a family of enzymes that controls the activity of other proteins in a cell by attaching chemical tags. That simple act helps determine cell survival or death. When it goes awry, a number of diseases ...
Aug 13, 2015
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Neuroscience
Zeroing in on Parkinson's: Researchers take multifaceted approaches to brain disease
For centuries, scientists have tried to crack the mystery of a devastating ailment once called "the shaking palsy." But Parkinson's disease, which causes tremors, muscle stiffness and difficulty walking, remains the second ...
Apr 21, 2023
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Oncology & Cancer
Molecular mechanisms behind AICAr drug; impact on ALL
AICAr (5-amino-4-imidazolecarboxamide riboside, also called Acadesine) has been found to inhibit cell proliferation and has cytotoxic potential for childhood acute lymphoblastic leukemia (ALL) cells. Much of the drug's cytotoxic ...
Jan 31, 2019
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Cardiology
A kinase identified as possible target to treat heart failure
An unexplored kinase in heart muscle cells may be a good target to treat heart failure, a disease that is only incrementally delayed by existing therapies. Failing human hearts showed reduced amounts of this kinase, and preclinical ...
Oct 31, 2019
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