Our genetic material is constantly exposed to damage, which the body's own proteins normally repair. One of these proteins works like a scanner, continually scouring the genetic material for signs of damage. Researchers from ...
Jan 24, 2013
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Almost 10 years after completion of the Human Genome Project in 2003, scientists are making progress toward the next major goal in applying the genetic information in that "Book of Life" in medicine, leaders of an international ...
Jan 23, 2013
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Viruses prompt oncogenic transformation by genetically altering infected cells. Several recent studies have demonstrated that viruses alter the expression of microRNAs, non-coding RNA molecules that can block the expression ...
Jan 16, 2013
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The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Jan 13, 2013
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(Medical Xpress)—Even when at rest, the human body is a flurry of activity. Like a microscopic metropolis locked in a state of perpetual rush hour traffic, the trillions of cells that make us who we are work feverishly ...
Jan 11, 2013
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Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice.
Jan 9, 2013
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Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive ...
Jan 9, 2013
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(Medical Xpress)—Scientists have identified 46 previously overlooked but potentially 'druggable' cancer targets, using a powerful new online approach that allows researchers to carry out 'virtual experiments' to quickly ...
Jan 2, 2013
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Australian scientists have shown in the laboratory how a 'transcription factor' causes breast cancer cells to develop an aggressive subtype that lacks sensitivity to estrogen and does not respond to known anti-estrogen therapies. ...
Dec 27, 2012
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(Medical Xpress)—The protein kinase Akt is a key regulator of cell growth, proliferation, metabolism, survival, and death. New work on Akt's role in cancer stem cell biology from the lab of senior author Honglin Zhou, MD, ...
Dec 20, 2012
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