Oncology & Cancer

Secret vulnerabilities of cancer's 'Death Star' protein revealed

Researchers at the Center for Genomic Regulation in Barcelona, Spain, and the Wellcome Sanger Institute near Cambridge, UK, have comprehensively identified the allosteric control sites found in the protein KRAS. These are ...

Genetics

Acetaldehyde dehydrogenases in liver zonation and liver cancer

A study, published in the journal Gene Expression and led by Brady Jin-Smith from the Department of Pathology at Tulane University, focuses on ALDHs, a group of key enzymes that catalyze the irreversible oxidation of various ...

Oncology & Cancer

Novel therapeutic target overcomes resistance to radiation therapy

A new study finds that radiation therapy (RT) suppresses a key protein called bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) and activates immune suppressive cells. These effects dampen the capacity ...

Oncology & Cancer

Study identifies strategy to avoid resistance to cancer therapy

Resistance to therapies is one of the obstacles to overcome in cancer treatments. Understanding the mechanisms of this resistance is essential to design strategies that favor tumor cell death. A study led by the Protein Kinases ...

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