Genetics

Epigenomic map reveals circuitry of 30,000 human disease regions

Twenty years ago this month, the first draft of the human genome was publicly released. One of the major surprises that came from that project was the revelation that only 1.5 percent of the human genome consists of protein-coding ...

Neuroscience

Brainstem neurons control both behaviour and misbehaviour

A recent study at the University of Helsinki reveals how gene control mechanisms define the identity of developing neurons in the brainstem. The researchers also showed that a failure in differentiation of the brainstem neurons ...

Genetics

Researchers identify master regulator genes of asthma

Researchers identify master regulator genes of asthma, provide new path forward in the study of asthma and the development of novel therapies. Identification of these master regulator genes provides a new path forward in ...

Immunology

St18 is a negative regulator of VEGF

Pro-inflammatory cytokines and pathogen-associated molecular patterns such as lipopolysaccharide (LPS) are known to activate NF-kB. NF-kB is a master regulator of inflammation and induces pro-inflammatory cytokines. Although ...

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