For much of the last decade, Dr. David Rawlings, director of Seattle Children's Research Institute's Center for Immunity and Immunotherapies, has dreamed of developing a therapy for children with type 1 diabetes that doesn't ...
Jun 3, 2020
0
887
Treatment that increases brain levels of an important regulatory enzyme may slow the loss of brain cells that characterizes Huntington's disease (HD) and other neurodegenerative disorders. In a report receiving advance online ...
Dec 18, 2011
1
0
The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Jan 13, 2013
0
0
Eating too much salt, which is common in many Western societies, is not only bad for our blood pressure and cardiovascular system—it could also adversely impact the immune system.
Feb 9, 2023
0
398
Cells from the immune system called CD4+ regulatory T cells, or simply Treg, are linked to tumor prognosis: the more Treg cells present in a tumor, the worst the prognosis. We know from previous research studies that Treg ...
Nov 29, 2021
0
1
Though cancer immunotherapy has become a promising standard-of-care treatment—and in some cases, perhaps a cure—for a wide variety of different cancers, it doesn't work for everyone, and researchers have increasingly ...
Oct 2, 2020
0
95
Regulatory T cells (Treg cells) are part of the system of checks and balances that prevents the immune response from going overboard and causing autoimmune disease. Although critically important for shaping the immune response ...
Jun 17, 2015
0
56
Biologically speaking, we carry the outside world within us. The food we ingest each day and the trillions of microbes that inhabit our guts pose a constant risk of infection—and all that separates us from these foreign ...
Jun 13, 2016
0
111
To eradicate pathogens or counteract inflammation, cells of the immune system move through often rapid blood flow toward peripheral disease sites, such as skin, gut or lung. Thus a goal of immunologists has been to define ...
Dec 27, 2017
0
395
Case Western Reserve University dental researcher Pushpa Pandiyan has discovered a new way to model how infection-fighting T cells cause inflammation in mice.
Feb 20, 2015
0
51
