As an approach to personalized medicine, a new Nature Communications study proposes that "mutational footprints" of DNA repair are a promising predictive genetic marker for determining which tumors will respond to certain ...
May 26, 2022
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Talazoparib, a new precision drug, can keep cancer in check in some men with advanced prostate cancer who have run out of options, a phase II clinical trial shows.
Aug 23, 2021
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Gene editing, or purposefully changing a gene's DNA sequence, is a powerful tool for studying how mutations cause disease, and for making changes in an individual's DNA for therapeutic purposes. A novel method of gene editing ...
Jun 10, 2021
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Over time, we accumulate genetic damage that accelerates the aging process, increasing the risk of carcinogenesis. DNA is continually challenged by genotoxic factors that affect its fragile structure, inhibiting cell functions. ...
Jun 1, 2021
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Mutations in a certain gene may increase a person's risk for an aggressive asbestos-related cancer called malignant mesothelioma, a new study claims.
May 21, 2021
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Researchers have found that people who live beyond 105 years tend to have a unique genetic background that makes their bodies more efficient at repairing DNA, according to a study published today in eLife.
May 4, 2021
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A new way to identify tumors that could be sensitive to particular immunotherapies has been developed using data from thousands of NHS cancer patient samples sequenced through the 100,000 Genomes Project. The MMRDetect clinical ...
Apr 26, 2021
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Scientists at the University of Cambridge have shown in animal studies that gene therapy may help repair some of the damage caused in chronic neurodegenerative conditions such as glaucoma and dementia. Their approach demonstrates ...
Mar 31, 2021
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Treatments that harness the immune system to fight cancer have greatly improved outcomes for some people with cancer. Scientists are learning more about why some people respond much better than others to these drugs.
Dec 1, 2020
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Unrelated mutations, when present in the blood, can lead to false positive results in men with advanced prostate cancer who are undergoing liquid biopsies. Such tests, which look for variants in the cell-free DNA that tumors ...
Nov 5, 2020
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