Oncology & Cancer

'PARP' drug sabotages DNA repair in pre-leukemic cells

Looking for ways to halt the uncontrolled growth of cancer cells, scientists at Johns Hopkins have found that a new class of drugs, called PARP inhibitors, may block the ability of pre-leukemic cells to repair broken bits ...

Genetics

A new breast cancer susceptibility gene

Mutations in a gene called XRCC2 cause increased breast cancer risk, according to a study published today in the American Journal of Human Genetics. The study looked at families that have a history of the disease but do not ...

Oncology & Cancer

New cancer algorithm flags genetic weaknesses in tumors

A new way to identify tumors that could be sensitive to particular immunotherapies has been developed using data from thousands of NHS cancer patient samples sequenced through the 100,000 Genomes Project. The MMRDetect clinical ...

Medical research

Harnessing the heart regeneration ability of marsupials

Wataru Kimura and colleagues at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan have discovered how the hearts of newborn marsupials retain the ability to regenerate for several weeks. Using this knowledge, ...

Genetics

More than just a DNA repair deficiency syndrome

Cockayne syndrome is a rare hereditary disease that can lead to dwarfism, neurological impairment, premature aging and a shortened life span. Skin symptoms include a striking sensitivity to UV rays and a dramatic loss of ...

Medical research

Immune cells of the blood might replace dysfunctional brain cells

Blood-circulating immune cells can take over the essential immune surveillance of the brain, this is shown by scientists of the German Center for Neurodegenerative Diseases and the Hertie Institute for Clinical Brain Research ...

Genetics

A new technique for correcting disease-causing mutations

Gene editing, or purposefully changing a gene's DNA sequence, is a powerful tool for studying how mutations cause disease, and for making changes in an individual's DNA for therapeutic purposes. A novel method of gene editing ...

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