Repairing or replacing injured tendons or similar load-bearing tissues represents one of the major challenges in clinical medicine. Natural tendons are water-rich tissues exhibiting outstanding mechanical strength and durability. ...
Apr 22, 2023
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Northwestern Medicine investigators have discovered a novel mechanism that connects circadian rhythm-controlled cellular metabolism and regeneration with muscle repair after injury, according to recent findings published ...
Mar 1, 2022
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Fanconi anemia (FA) is a genetic disease affecting small children characterized by bone-marrow failure, developmental abnormalities and predisposition to multiple forms of cancer. The molecular mechanisms behind FA are inherited ...
Oct 14, 2020
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Through a global gene expression analysis (transcriptomic), the researchers were able to find and confirm a genetic signature common to genodermatoses in patients' cells. The profile targets cellular activation and alteration ...
Mar 5, 2019
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Mutations driving cancer development leave behind specific 'scars," so-called mutational signatures, in the genome. In principle, they allow for profiling of the cancer type and its development—but the noisy environment ...
May 9, 2018
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Mitochondria are cellular organelles with their own DNA. Their role in power generation makes them susceptible to oxidative damage, including the formation of DNA-damaging chemical complexes called adducts.
Feb 23, 2018
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DNA is the computer code that programs every event in the body. Despite the importance of DNA fidelity, as the body develops, cells grow and replicate, DNA is constantly turned over. This repeated process can compromise the ...
Aug 31, 2017
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Early-stage colon cancer patients could benefit in the future from specific genetic tests that forecast their prognosis and help them make the right decision regarding chemotherapy. Two of the biomarkers involved are the ...
Jul 26, 2017
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When cancer cells divide they often make mistakes which can alter their DNA. While this can give cancer cells an upper hand, it can also be their downfall.
Mar 17, 2017
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People who are frequently depressed or anxious may run a higher risk of dying from certain types of cancer, researchers said on Thursday.
Jan 26, 2017
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