Men with a particular genetic subtype of the steroid biosynthesis enzyme HSD3B1 may exhibit resistance to combined radiation and hormone therapy for prostate cancer, according to new Cleveland Clinic-led research published ...
Nov 20, 2023
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Metabolites called nucleotides are the building blocks of DNA and can impact cancer's sensitivity or resistance to chemotherapy and radiation in brain cancer. Findings from researchers at the University of Michigan Health ...
Nov 2, 2023
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A new research paper titled "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex" has been published in Aging.
Jun 13, 2023
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Vanderbilt researchers have developed an active machine learning approach to predict the effects of tumor variants of unknown significance, or VUS, on sensitivity to chemotherapy. VUS, mutated bits of DNA with unknown impacts ...
Aug 9, 2022
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The ongoing fight of science against cancer has made great strides, but cancer cells have not made it easy. The complexity of cancer cells and their adaptive evolutionary nature complicate the search for effective cures. ...
Feb 16, 2021
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Plexin-B2, an axon guidance protein in the central nervous system (CNS), plays an important role in wound healing and neural repair following spinal cord injury (SCI), according to research conducted at the Icahn School of ...
Mar 2, 2020
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A recent study led by University of Kentucky researchers illuminates a new way that tobacco smoke may promote the development of lung cancer: inhibiting a DNA repair process called nucleotide excision repair (NER). The results ...
Oct 17, 2016
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A team of Georgia State University researchers is fighting cancers using a combination of therapies and recently found ways that radiation could maximize responses to novel immune-based therapeutic approaches to fight cancer.
Feb 2, 2016
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Cancer cells with mutations in BRCA1 or BRCA2 genes, which serve a vital role in preserving the integrity of the genetic code, are key targets for cancer therapeutics. Yet, few agents can selectively eliminate cells deficient ...
Nov 5, 2015
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Scientists at The University of Texas MD Anderson Cancer Center may have discovered why some brain cancer patients develop resistance to standard treatments including radiation and the chemotherapy agent temozolomide.
Mar 2, 2015
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